Abstract
The crystal structure of a transplatin-derived complex, trans-[Pt(NH3)(2)(dmtu)(2)]Cl-2 (dmtu = N,N (') -dimethylthiourea) was determined by X-ray crystallography and its antimicrobial activities were evaluated by minimum inhibitory concentration. The structure consists of trans-[Pt(NH3)(2)(dmtu)(2)](2+) cation and two chloride ions. In trans-[Pt(NH3)(2)(dmtu)(2)](2+), the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 178.6 degrees, respectively. The H-1 and C-13 NMR spectral data indicated the coordination of both ligands to platinum(II). The results of antimicrobial studies showed that the complex exhibited significant activity against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), while relatively poor activities were observed against molds (Aspergillus niger, Penicillium citrinum) and yeasts (Candida albicans, Saccharomyces cerevisiae).