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Cu(I)-Catalyzed Regioselective Synthesis of Pyrazolo[5,1-c]-1,2,4-triazoles
Journal article   Peer reviewed

Cu(I)-Catalyzed Regioselective Synthesis of Pyrazolo[5,1-c]-1,2,4-triazoles

Davit Jishkariani, C. Dennis Hall, Alexander A. Oliferenko, David Leino and Alan R. Katritzky
Journal of organic chemistry, Vol.77(13), pp.5813-5818
06/07/2012
DOI: https://doi.org/10.1021/jo300611a
PMID: 22612460

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Cycloadditions of terminal alkynes to 1,2,4-triazolium N-imides in the presence of base and Cu(I) afford pyrazolo[5,1-c]-1,2,4-triazoles regioselectively. The scope of alkynes, the influence of the electronic nature of the leaving group, and variations in the 1-alkyl substituent were examined. Quantum chemical calculations were employed to explain the distinct reactivity of the propiolates.

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