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Cu(II)-catalyzed tandem synthesis of 2-imino[1,3]benzothiazines from 2-aminoaryl acrylates via thioamidation and concomitant chemoselective thia-Michael addition
Journal article   Peer reviewed

Cu(II)-catalyzed tandem synthesis of 2-imino[1,3]benzothiazines from 2-aminoaryl acrylates via thioamidation and concomitant chemoselective thia-Michael addition

Rakesh K. Saunthwal, Monika Patel, Sushil Kumar and Akhilesh K. Verma
Tetrahedron letters, Vol.56(5), pp.677-681
28/01/2015
DOI: https://doi.org/10.1016/j.tetlet.2014.12.058

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
An efficient copper-catalyzed tandem approach for the synthesis of 2-imino[1,3]benzothiazines by the reaction of easily accessible 2-aminoaryl acrylates with isothiocyanates via in situ thioamidation and concomitant chemoselective intramolecular thia-Michael addition is described. Intramolecular cyclization was selectively triggered by the nitrogen 'b' of the thiourea intermediate P. (C) 2014 Elsevier Ltd. All rights reserved.

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