Abstract
Abstract
Abstract
Background:
Interindividual genetic variations and environmental factors both play pivotal roles in the pathogenesis of metabolic syndrome (MetS). The rationale of this study conducted was to analyze the association of Matrix Metalloproteinase (
MMP
) gene variants,
MMP-1 (-1607 1G/2G)
and
MMP-2 (-1306 C/T)
with susceptibility to MetS and its effect on serum
MMP
level.
Methods:
Study involved 370 subjects with 1:1 distribution of cases and controls. Patients were recruited according to modified NCEP-ATP III criteria for MetS. Clinical, biochemical analysis, PCR-RFLP and ELISA methods were employed for genotyping and estimation of serum
MMP
level.
Results:
Significantly (p<0.001) higher Serum
MMP-2
(39.13±19.96 ng/ml) was detected in cases as compared to controls. The
MMP-2 (-1306 C/T)
was significantly associated with the risk of MetS. The variant genotype TT was significantly associated with increased risk of MetS. (p=0.032; OR=2.31; 95%CI=1.07–4.97). No significant association of
MMP-1(-1607 1G/2G)
was found with risk of MetS.
Conclusion:
Our study concluded that presence of
MMP-2 (-1306 C/T)
might be associated the risk of MetS. Serum
MMP2
level was significantly higher in patients and correlated with clinical parameters of MetS. Clinical implication of the work may help to identify the individuals with high risk of MetS and further complications.