Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues

Naim H. Al-Said; Khaled Q. Shawakfeh; Wasim N. Abdullah

doi:10.3390/10121446

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Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues

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Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues

Naim H. Al-Said, Khaled Q. Shawakfeh and Wasim N. Abdullah

Molecules (Basel, Switzerland), Vol.10(12), pp.1446-1457

31/12/2005

DOI: https://doi.org/10.3390/10121446

PMCID: PMC6147633

PMID: 18007541

Abstract

Duocarmycin

free-radicals

indole

intramolecular cyclization

pyrroloquinoline

Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2-carboxylate derivatives, through the less favorable 6 - endo - trig cyclization mode.

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Title: Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues
Creators - without role: Naim H. Al-Said - Jordan University of Science and Technology
Khaled Q. Shawakfeh - Jordan University of Science and Technology
Wasim N. Abdullah - Jordan University of Science and Technology
Publication Details: Molecules (Basel, Switzerland), Vol.10(12), pp.1446-1457
Publisher: MDPI
Identifiers: 9920846408331
Academic Unit: King Saud Bin Abdulaziz University for Health Sciences
Language: English
Resource Type: Journal article