Abstract
2-Pyridone is considered as one of the most famous efficient pharmaceutical compounds. Many approaches were discovered to synthesize 2-pyridone. In this present research, chloroacetylation of benzylamine at simple conditions, EtONa/EtCOONa produced
-benzyl-2-chloroacetamide
. Compound
was allowed to react with different reagents. These reagents are acetylacetone, ethyl cyanoacetate, ethyl acetoacetate, and diethyl malonate, creating
with a good yield. The structures of the prepared compounds were elucidated by spectral data (IR,
HNMR, and
CNMR). The synthesized compound was tested for its antimicrobial activity against the Gram-positive (
) and the Gram-negative (
) bacteria. In addition, the antifungal activities of the compounds were tested against two fungi (
and
). Molecular docking studies were applied using the Autodock vina method. Theoretical methods prove all the experimental results by using molecular docking using Autodock vina and by ADEMT studies. The docking results represent that compound
had the best docking free energy, and it is the effective compound toward the selected bacterial and fungal proteins. ADME studies showed that the only compound
could cross the blood–brain barrier, and compound
was predicted to be soluble.