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Cyclodesulfurization of Substituted Thiosemicarbazides into 1,3,4-Oxadiazoles via Hydrazonoyl Chlorides
Journal article   Peer reviewed

Cyclodesulfurization of Substituted Thiosemicarbazides into 1,3,4-Oxadiazoles via Hydrazonoyl Chlorides

Hatem A. Abdel-Aziz, Mashooq A. Bhat and Mohamed Ghazzali
Phosphorus, sulfur, and silicon and the related elements, Vol.189(9), pp.1328-1336
02/09/2014

Abstract

1,3,4-oxadiazoles Cyclodesulfurization hydrazonoyl chlorides thiosemicarbazides
The reaction of thiosemicarbazides 1a-h with hydrazonoyl chlorides 2a-g at ambient temperature, in the presence of triethylamine yielded, in each case, two products. The structure of these compounds was confirmed as 1,3,4-oxadiazoles 14a-h and hydrazonothioates 15a-g. The structure of 15b was confirmed through single crystal X-ray diffraction. A mechanism was proposed for this cyclodesulfurization reaction.

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