Abstract
The organic extract of liquid cultures of the marine-derived
sp. was investigated. Fractionation of the extracts of the fungus led to the purification and identification of two new compounds, penicillatides A (
) and B (
), together with the previously reported cyclo(
-Pro
-Phe) (
) and cyclo(
-Pro
-Phe) (
). The structures of compounds
-
were assigned by extensive interpretation of their NMR and high-resolution mass spectrometry (HRMS). The antiproliferative and cytotoxic activities of the compounds against three human cancer cell lines as well as their antimicrobial activity against several pathogens were evaluated. Compounds
-
displayed variable cytotoxic and antimicrobial activities.