Abstract
From the methanol extract of the roots of
Crossopetalum gaumeri, four new highly cytotoxic cardenolides, securigenin-3β-
O-β-6-deoxyguloside (
2), 19-hydroxy-sarmentogenin-3β-
O-β-6-deoxyguloside (
4), sarmentogenin-3β-
O-[α-allosyl-(1→4)-β-6-deoxyalloside] (
5), and securigenin-3β-
O-[α-allosyl-(1→4)-β-6-deoxyalloside] (
6) were isolated. The dichloromethane extract afforded the new diterpene 3,15-dihydroxy-18-norabieta-3,8,11,13-tetraene (
7) as well as the new triterpene 2,3,7-trihydroxy-6-oxo-1,3,5(10),7-tetraene-24-nor-friedelane-29-oic acid methylester (
11). The new terpenoids lack cytotoxicity and the antibacterial activity is moderate to low.