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Cytotoxic chemotherapy administered to two patients with partially refractory leukaemia while receiving intensive care treatment
Journal article   Peer reviewed

Cytotoxic chemotherapy administered to two patients with partially refractory leukaemia while receiving intensive care treatment

K A Al-Anazi and S Jacobs
Supportive care in cancer, Vol.12(10), pp.739-742
10/2004
DOI: https://doi.org/10.1007/s00520-004-0665-7
PMID: 15243793

Abstract

Acute Disease Adolescent Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bone Marrow Transplantation Humans Intensive Care Units Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Promyelocytic, Acute - complications Leukemia, Promyelocytic, Acute - drug therapy Male Respiration, Artificial
Administration of cytotoxic chemotherapy to a mechanically ventilated patient is a major undertaking. Induction of remission of leukaemia under such circumstances is an extremely rare event. We report two patients with partially refractory acute myeloid leukaemia who achieved remission of their leukaemia after receiving chemotherapy in the intensive care unit. Both patients were subsequently cured by allogeneic bone marrow transplant.

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