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Cytotoxic xenia diterpenoids from the soft coral Xenia umbellata
Journal article   Peer reviewed

Cytotoxic xenia diterpenoids from the soft coral Xenia umbellata

Ali A H El-Gamal, Shang-Kwei Wang and Chang-Yih Duh
Journal of natural products (Washington, D.C.), Vol.69(3), pp.338-341
01/03/2006
DOI: https://doi.org/10.1021/np058093r
PMID: 16562830

Abstract

Animals Anthozoa - chemistry Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Drug Screening Assays, Antitumor Molecular Structure Nuclear Magnetic Resonance, Biomolecular Taiwan Tumor Cells, Cultured
Eleven new xenia diterpenoids, umbellacins A-G (1-7), 14,15-epoxy-xeniolide H (8), 3-acetyl-14,15-epoxy-xeniolide H (9), and umbellacins H and I (10, 11), were isolated from a methylene chloride-soluble fraction of the soft coral Xenia umbellata. The structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

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