Abstract
In this post-hoc analysis of the PermiT trial, we examined the association of protein intake with 90-day mortality and protein biomarkers in critically ill patients. Methods: The PermiT (Permissive Underfeeding versus Target Enteral Feeding in Adult Critically Ill Patients) trial randomized 894 patients to permissive underfeeding (goal 40-60% caloric requirement) or standard feeding (goal 70-100% caloric requirement) with similar target protein intake (1.2-1.5 g/kg/day); and found no difference in the 90-day mortality between the two groups.