Abstract
To discover new bioactive lead compounds for medicinal purposes, herein, (E)-3-(substituted-amino)-1-thiophen-2-yl-prop-2-en-1-ones 3-8, aminopyridines 9-11, benzylamine 12, nicotinamide 13, pyrimidines 14, 15, hexanoic acid 16 and triazolopyrimidine 19 were prepared and tested for cytotoxic activity. Results showed that the tested compounds exhibited a remarkable activity, especially compounds 3 and 19 with IC50 values (55.2 and 50.49 mu M, respectively) compared to doxorubicin (IC50 = 71.8 mu M) as a reference drug.