Abstract
In this work, synthesis and biological evaluation of series of hydrazides 2a-e and amides 4a-d, 6a-g functionality have been reported. All sixteen compounds were synthesized using short and convenient one high yielding step starting from isatoic anhydride derivatives. Some newly synthesized compounds were subjected to in-vitro antibacterial and antifungal screening. Compound 4b could be considered as the most active members in this investigation with a broad spectrum of antibacterial activity against two types of Gram-positive bacteria, two types of Gram-negative bacteria together with an appreciable antifungal activity against A. fumigatus, S. cerevisiae and C. albicans. This compound found to be more potent than streptomycin against B. subcilils and Escherichia coli. Neversless, 4b showed greater effect than well known antifungal agent such as clotrimazole against A. fumigatus and can serve as potential lead molecules for further investigation.
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