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DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex
Journal article   Peer reviewed

DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex

Rajamuthy Vikneswaran, Naser Eltaher Eltayeb, Subramaniam Ramesh and Rosiyah Yahya
Bulletin of the Chemical Society of Japan, Vol.88(8), pp.1156-1158
2015
DOI: https://doi.org/10.1246/bcsj.20150084

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
A new mononuclear zinc complex of N-phenyl-substituted thiophene thiosemicarbazone ligand [Zn(Httsc-N-Ph)(2)] was synthesized and characterized, and investigated as nuclease mimic. As compared to carboplatin, a much greater activity against He La cells is exhibited by [Zn(Httsc-N-Ph)(2)] which binds to DNA through an intercalation mechanism.

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