Abstract
The interaction between heavy metals in the environment and DNA still under investigation, the association of cadmium and DNA repair was conducted in a current study represented by apurinic/apyrimidinic endonuclease (APE1) Asp148Glu (rs3136820) and X-ray repair cross-complementing group 1(XRCC1) Arg399Gln (28152) G>A, using CTTP-PCR, results showed non-significant changes of Cd (p 0.965) in the station workers and the control group. The Cd level in station workers according to work type showed non-significant differences (p 0.291). The APE1 genotyping in study groups showed significant association with all genotypes in station workers (p 0.009, p 0.024), non-significant association with allele frequency (p 0.066). The association XRCC 1 genotyping showed non-significant results (p 0.479, 0.0311), and non-significant with allele frequency (p 0.164). The distribution of APE 1 and XRCC 1 genotyping in the station workers according to work types showed non-significant association with APE 1 (p 0. 255), and significant with allele frequency (p 0.000). The XRCC1 showed non-significant association of GA, GG and workers (p 0.265) and significant association of G allele (p 0.001). The Cd levels, according to APE 1and XRCC1 genotyping showed non-significant differences (p 0.193, p 0.0.76) respectively. conclusion: a significant association of APE 1 with station workers, but didn't association with Cd level and non-significant association of XRCC 1 genotyping with station works and Cd level.