Abstract
Fungal keratitis is a major sight-threatening corneal infection: and mycotic keratitis is more common in tropical parts of the world including India.
Aspergillus flavus
and
Fusarium
are the predominant causative agents of corneal infection. We extracted conidial surface proteins of
A. flavus
from saprophyte and clinical isolates and analyzed the proteins using high resolution mass spectrometry. The data revealed ecotype specific alteration in surface proteome since the proteome profile of the clinical isolates and saprophyte showed significant differences. Detailed examination of the mass spec data of RodA proteins extracted from polyacrylamide gels revealed the presence of two proteoforms of this protein. We also identified the mechanism of formation of these two isoforms. Detailed analysis of this data and the conclusions derived are described in the article, “Identification of the proteoforms of surface localized Rod A of
A. flavus
and determination of the mechanism of proteoform generation” [1].