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De novo design of a beta alpha beta motif
Journal article   Peer reviewed

De novo design of a beta alpha beta motif

Huanhuan Liang, Hao Chen, Keqiang Fan, Ping Wei, Xianrong Guo, Changwen Jin, Chen Zeng, Chao Tang and Luhua Lai
Angewandte Chemie (International ed.), Vol.48(18), pp.3301-3303
2009
DOI: https://doi.org/10.1002/anie.200805476
PMID: 19347908

Abstract

Amino Acid Motifs - genetics Amino Acid Sequence Molecular Sequence Data Mutation Protein Folding Proteins - chemistry Proteins - genetics
A designer monomeric protein with a beta alpha beta fold--two parallel beta strands connected by an alpha helix (see structure)--was constructed solely from coded amino acids. The high thermal stability of the structure is due to a large extent to tryptophan-tryptophan interactions between the two beta strands.

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