Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

Edward Burn; Seng Chan You; Anthony G Sena; Kristin Kostka; Hamed Abedtash; Maria Tereza F Abrahão; Amanda Alberga; Heba Alghoul; Osaid Alser; Thamir M Alshammari; Maria Aragon; Carlos Areia; Juan M Banda; Jaehyeong Cho; Aedin C Culhane; Alexander Davydov; Frank J DeFalco; Talita Duarte-Salles; Scott DuVall; Thomas Falconer; Sergio Fernandez-Bertolin; Weihua Gao; Asieh Golozar; Jill Hardin; George Hripcsak; Vojtech Huser; Hokyun Jeon; Yonghua Jing; Chi Young Jung; Benjamin Skov Kaas-Hansen; Denys Kaduk; Seamus Kent; Yeesuk Kim; Spyros Kolovos; Jennifer C E Lane; Hyejin Lee; Kristine E Lynch; Rupa Makadia; Michael E Matheny; Paras P Mehta; Daniel R Morales; Karthik Natarajan; Fredrik Nyberg; Anna Ostropolets; Rae Woong Park; Jimyung Park; Jose D Posada; Albert Prats-Uribe; Gowtham Rao; Christian Reich; Yeunsook Rho; Peter Rijnbeek; Lisa M Schilling; Martijn Schuemie; Nigam H Shah; Azza Shoaibi; Seokyoung Song; Matthew Spotnitz; Marc A Suchard; Joel N Swerdel; David Vizcaya; Salvatore Volpe; Haini Wen; Andrew E Williams; Belay B Yimer; Lin Zhang; Oleg Zhuk; Daniel Prieto-Alhambra; Patrick Ryan; Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa

doi:10.1038/s41467-020-18849-z

Back

Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

Journal article

Open access

Peer reviewed

Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

Edward Burn, Seng Chan You, Anthony G Sena, Kristin Kostka, Hamed Abedtash, Maria Tereza F Abrahão, Amanda Alberga, Heba Alghoul, Osaid Alser, Thamir M Alshammari, …

Nature communications, Vol.11(1), pp.5009-5009

06/10/2020

DOI: https://doi.org/10.1038/s41467-020-18849-z

PMCID: 7538555

PMID: 33024121

Abstract

Adult

Age Factors

Aged

Aged, 80 and over

Cohort Studies

Comorbidity

Coronavirus Infections - drug therapy

Coronavirus Infections - epidemiology

COVID-19

Female

Hospitalization

Humans

Influenza, Human - drug therapy

Influenza, Human - epidemiology

Male

Middle Aged

Pandemics

Pneumonia, Viral - drug therapy

Pneumonia, Viral - epidemiology

Prevalence

Republic of Korea - epidemiology

Sex Factors

Spain - epidemiology

United States - epidemiology

Young Adult

Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.

Files and links (1)

url

https://doi.org/10.1038/s41467-020-18849-zView

Published (Version of record) Open

Metrics

1 Record Views

See more details

Details

Title: Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study
Creators - without role: Edward Burn - Nuffield Orthopaedic Centre
Seng Chan You - Ajou University
Anthony G Sena - Janssen
Kristin Kostka - IQ Solutions
Hamed Abedtash - Eli Lilly
Maria Tereza F Abrahão - Universidade de São Paulo
Amanda Alberga - Observational Health Data Sciences and Informatics Network, Alberta, Canada
Heba Alghoul - Islamic University of Gaza
Osaid Alser - Massachusetts General Hospital
Thamir M Alshammari - King Saud University
Maria Aragon - Institut Universitari d'Investigació en Atenció Primària Jordi Gol
Carlos Areia - University of Oxford
Juan M Banda - Georgia State University
Jaehyeong Cho - Ajou University
Aedin C Culhane - Dana-Farber Cancer Institute
Alexander Davydov - Belarusian State Medical University
Frank J DeFalco - Janssen
Talita Duarte-Salles - Institut Universitari d'Investigació en Atenció Primària Jordi Gol
Scott DuVall - University of Utah
Thomas Falconer - Columbia University
Sergio Fernandez-Bertolin - Institut Universitari d'Investigació en Atenció Primària Jordi Gol
Weihua Gao - AbbVie
Asieh Golozar - Regeneron
Jill Hardin - Janssen
George Hripcsak - Columbia University
Vojtech Huser - United States National Library of Medicine
Hokyun Jeon - Ajou University
Yonghua Jing - AbbVie
Chi Young Jung - Daegu Catholic University Medical Center
Benjamin Skov Kaas-Hansen - Zealand University Hospital Køge
Denys Kaduk - V. N. Karazin Kharkiv National University
Seamus Kent - National Institute for Health and Care Excellence
Yeesuk Kim - Hanyang University
Spyros Kolovos - Nuffield Orthopaedic Centre
Jennifer C E Lane - Nuffield Orthopaedic Centre
Hyejin Lee - Health Insurance Review and Assessment Service
Kristine E Lynch - University of Utah
Rupa Makadia - Janssen
Michael E Matheny - Vanderbilt University Medical Center
Paras P Mehta - University of Arizona
Daniel R Morales - University of Dundee
Karthik Natarajan - Columbia University
Fredrik Nyberg - University of Gothenburg
Anna Ostropolets - Columbia University
Rae Woong Park - Ajou University
Jimyung Park - Ajou University
Jose D Posada - Stanford University
Albert Prats-Uribe - Nuffield Orthopaedic Centre
Gowtham Rao - Janssen
Christian Reich - IQ Solutions
Yeunsook Rho - Nuffield Orthopaedic Centre
Peter Rijnbeek - Erasmus MC
Lisa M Schilling - University of Colorado Anschutz Medical Campus
Martijn Schuemie - Janssen
Nigam H Shah - Stanford University
Azza Shoaibi - Janssen
Seokyoung Song - Catholic University of Daegu
Matthew Spotnitz - Columbia University
Marc A Suchard - University of California, Los Angeles
Joel N Swerdel - Janssen
David Vizcaya - Bayer
Salvatore Volpe - Columbia University
Haini Wen - Shuguang Hospital
Andrew E Williams - Tufts Institute for Clinical Research and Health Policy Studies, Boston, MA, USA
Belay B Yimer - Versus Arthritis
Lin Zhang - Chinese Academy of Medical Sciences & Peking Union Medical College
Oleg Zhuk - Odysseus Data Services, Inc., Cambridge, MA, USA
Daniel Prieto-Alhambra - Nuffield Orthopaedic Centre
Patrick Ryan - Janssen
Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Publication Details: Nature communications, Vol.11(1), pp.5009-5009
Grant note: R01 LM006910 / NLM NIH HHS SRF-2018-11-ST2-004 / Department of Health UL1 TR002544 / NCATS NIH HHS MR/K501256/1 / Medical Research Council RES 13-457 / ORD VA 21605 / Versus Arthritis
Identifiers: 9949966008331
Academic Unit: King Saud University
Language: English
Resource Type: Journal article