Abstract
Curcumin is one of the most researched phytochemicals by pharmacologists and formulation scientists to unleash its potential therapeutic benefits and tackle inherent biopharmaceutic problems. In this study, the native beta-cyclodextrin (CD) and three derivatives, namely, Captisol (sulfobutyl ether beta-CD), hydroxypropyl beta-cyclodextrin, and hydroxyethyl beta-cyclodextrin were investigated for inclusion complexes with curcumin using two preparation methods (physical mixing and solvent evaporation). The prepared complexes were studied for docking, solubility, FTIR, DSC, XRD, and dissolution rates. The best-fitting curcumin: cyclodextrins (the latter of the two CDs) were evaluated for cytotoxicity using human breast cell lines (MCF-7). Dose-dependent cytotoxicity was recorded as IC50% for curcumin, curcumin: hydroxyethyl beta-cyclodextrin, and curcumin: hydroxypropyl beta-cyclodextrin were 7.33, 7.28, and 19.05 mu g/mL, respectively. These research findings indicate a protective role for the curcumin: hydroxypropyl beta-cyclodextrin complex on the direct cell lines of MCF-7.