Design, Synthesis, Characterization, Swelling and in Vitro Drug Release Behavior of Composite Hydrogel Beads Based on Methotrexate and Chitosan Incorporating Antipyrine Moiety

E. M. Abdel Bary; Ammar N. Harmal; Ali Saeed; Moustafa A. Gouda

doi:10.1080/03602559.2018.1447126

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Design, Synthesis, Characterization, Swelling and in Vitro Drug Release Behavior of Composite Hydrogel Beads Based on Methotrexate and Chitosan Incorporating Antipyrine Moiety

E. M. Abdel Bary, Ammar N. Harmal, Ali Saeed and Moustafa A. Gouda

Polymer-plastics technology and engineering, Vol.57(18), pp.1906-1914

12/12/2018

DOI: https://doi.org/10.1080/03602559.2018.1447126

Abstract

Physical Sciences

Polymer Science

Science & Technology

Novel biodegradable pH and thermal-responsive hydrogels were prepared for controlled drug delivery studies via reaction of chitosan with 4-chloroacetylantipyrine in DMF/H2O, followed by heating of the formed poly [acetylantipyrine-chitosan] with glutaraldehyde as a crosslinking agent to give the hydrogels. These hydrogels were subjected to equilibrium swelling studies at different temperatures (25 degrees C, 37 degrees C and 45 degrees C) in solutions of pH 2.1 and 7.4. Methotrexate (MTX) was entrapped in the hydrogels, and drug release studies were carried out at 37 degrees C in solutions at pH 2.1 and 7.4. [GRAPHICS]

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Title: Design, Synthesis, Characterization, Swelling and in Vitro Drug Release Behavior of Composite Hydrogel Beads Based on Methotrexate and Chitosan Incorporating Antipyrine Moiety
Creators - without role: E. M. Abdel Bary - Mansoura University
Ammar N. Harmal - Mansoura University
Ali Saeed - Mansoura University
Moustafa A. Gouda - Taibah University
Publication Details: Polymer-plastics technology and engineering, Vol.57(18), pp.1906-1914
Publisher: Taylor & Francis
Number of pages: 9
Identifiers: 9929850508331
Academic Unit: Taibah University
Language: English
Resource Type: Journal article