Abstract
The current project deals with designing and synthesizing of colorimetric chemosensors to detect the cations in the aqueous medium and biological sample. To achieve this goal a new series of quinazolinone derivatives were synthesized via reaction of the novel 6-nitro-2-propyl-4H-benzo [d] [1,3]oxazin-4-one (3) with selected nitrogen nucleophiles, namely, formamide, hydrazine hydrate, hydroxylamine hydrochloride, O-phenylendiamine, O-aminophenol and O-aminothiophenol, urea and/or thiourea. Structures of the new compounds have been investigated depending on their spectral data (IR, (HNMR)-H-1, C-13 NMR and MS) and elemental analyses. Some of the newly synthesized products exhibited a significant response as chemosensors for some cations detection. The synthesized chemosensors 11(a) and 11(b) showed high-selectivity and specificity towards cooper (Cu-II) and mercury (Hg-II) cations detection through exhibiting colormetric responses. Chemosensors 7 and 10(b) showed high selectivity toward cadmium (Cd-II) cation, whilst other examined compounds (9(b,c), 10(a), 12, 13, and 14) did not exhibit colorimetric response in all cation's samples.