Abstract
In continuation of our research work to discover novel selective antimicrobial agents, new derivatives of thiochromene derivatives 4, 7-18a,b were constructed. These novel candidates were evaluated in vitro for their antimicrobial potential toward B. subtilis and S. aureus as examples of Gram-positive bacteria, E. coli and P. aeruginosa as examples of Gram-negative bacteria, A. flavus and C. albicans as examples of fungi. The results displayed that all the screened compounds 4 and 7-18a,b recorded moderate to excellent antimicrobial activity especially compound 17 was the most active toward all the tested microbes (zone of inhibition = 23-27 mm). Concerning antifungal activity, compounds 14 and 17 displayed higher antifungal activity against C. albicans potency (zone of inhibition = 23, 20 mm, respectively) than amphotericin B (zone of inhibition = 19 mm). Molecular docking simulation study of the novel thiochromene derivatives 4, 7-18a,b within dihydropteroate synthase active site displayed good scoring with various binding interactions within the active site.