Abstract
The objective of this research work was to develop chitosan based polymeric complex of rosuvastatin for improving its solubility and stability. The chitosan-rosuvastatin complex was prepared by using amide coupling reaction. The coupling reaction was carried out by reaction between the amine groups of the chitosan and the activated carboxylic group of the rosuvastatin. The prepared complex was characterized by its H-1-NMR, FTIR, X-ray diffraction, and zeta potential. The chitosan-rosuvastatin complex was subjected for its muco-adhesive property, solubility studies, acid degradation studies, and the radical scavenging activity. The results suggested that the chitosan-rosuvastatin complex retains the muco-adhesiveness of the parent chitosan; its solubility was approximately 250-fold higher than that of pure rosuvastatin; it demonstrated nearly 3-fold higher stability than the rosuvastatin; and it exhibited higher DPPH radical scavenging activity as compared to the rosuvastatin. Based on the results, it has been concluded that the chitosan-rosuvastatin complex has a potential to demonstrate enhanced bioavailability in vivo. However, further in vivo studies are recommended.