Design and Implementation of the International Genetics and Translational Research in Transplantation Network

Brendan J. Keating; Jessica van Setten; Pamala A. Jacobson; Michael V. Holmes; Shefali S. Verma; Hareesh R. Chandrupatla; Nikhil Nair; Hui Gao; Yun R. Li; Bao-Li Chang; Chanel Wong; Randy Phillips; Brian S. Cole; Eyas Mukhtar; Weijia Zhang; Hongzhi Cao; Maede Mohebnasab; Cuiping Hou; Takesha Lee; Laura Steel; Oren Shaked; James Garifallou; Michael B. Miller; Konrad J. Karczewski; Abdullah Akdere; Ana Gonzalez; Kelsey M. Lloyd; Daniel McGinn; Zach Michaud; Abigail Colasacco; Monkol Lek; Yao Fu; Mayur Pawashe; Toumy Guettouche; Aubree Himes; Leat Perez; Weihua Guan; Baolin Wu; David Schladt; Madhav Menon; Zhongyang Zhang; Vinicius Tragante; Nicolaas de Jonge; Henny G. Otten; Roel A. de Weger; Ed A. van de Graaf; Carla C. Baan; Olivier C. Manintveld; Iwijn De Vlaminck; Brian D. Piening; Calvin Strehl; Mary Shaw; Harold Snieder; Goran B. Klintmalm; Jacqueline G. O'Leary; Sandra Amaral; Samuel Goldfarb; Elizabeth Rand; Joseph W. Rossano; Utkarsh Kohli; Peter Heeger; Eli Stahl; Jason D. Christie; Maria Hernandez Fuentes; John E. Levine; Richard Aplenc; Eric E. Schadt; Barbara E. Stranger; Jolanda Kluin; Luciano Potena; Andreas Zuckermann; Kiran Khush; Alhusain J. Alzahrani; Fahad A. Al-Muhanna; Amein K. Al-Ali; Rudaynah Al-Ali; Abdullah M. Al-Rubaish; Samir Al-Mueilo; Edna M. Byrne; David Miller; Stephen I. Alexander; Suna Onengut-Gumuscu; Stephen S. Rich; Manikkam Suthanthiran; Helio Tedesco; Chee L. Saw; Jiannis Ragoussis; Abdallah G. Kfoury; Benjamin Horne; John Carlquist; Mark B. Gerstein; Roman Reindl-Schwaighofer; Rainer Oberbauer; Cisca Wijmenga; Scott Palmer; Alexandre C. Pereira; Javier Segovia; Luis A. Alonso-Pulpon; Manuel Comez-Bueno; Carlos Vilches; Natalia Jaramillo; Martin H. de Borst; Maarten Naesens; Ke Hao; DanielG MacArthur; Suganthi Balasubramanian; Peter J. Conlon; Graham M. Lord; Marylyn D. Ritchie; Michael Snyder; Kim M. Olthoff; Jason H. Moore; Effie W. Petersdorf; Malek Kamoun; Jun Wang; Dimitri S. Monos; Paul I. W. de Bakker; Hakon Hakonarson; Barbara Murphy; Matthew B. Lankree; Pablo Garcia-Pavia; William S. Oetting; Kelly A. Birdwell; Stephan J. L. Bakker; Ajay K. Israni; Abraham Shaked; Folkert W. Asselbergs; Int Genetics & Translational Res T

doi:10.1097/TP.0000000000000913

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Design and Implementation of the International Genetics and Translational Research in Transplantation Network

Journal article

Peer reviewed

Design and Implementation of the International Genetics and Translational Research in Transplantation Network

Brendan J. Keating, Jessica van Setten, Pamala A. Jacobson, Michael V. Holmes, Shefali S. Verma, Hareesh R. Chandrupatla, Nikhil Nair, Hui Gao, Yun R. Li, Bao-Li Chang, …

Transplantation, Vol.99(11), pp.2401-2412

11/2015

DOI: https://doi.org/10.1097/TP.0000000000000913

PMCID: PMC4623847

PMID: 26479416

Abstract

Immunology

Life Sciences & Biomedicine

Science & Technology

Surgery

Transplantation

Background. Genetic association studies of transplantation outcomes have been hampered by small samples and highly complex multifactorial phenotypes, hindering investigations of the genetic architecture of a range of comorbidities which significantly impact graft and recipient life expectancy. We describe here the rationale and design of the International Genetics & Translational Research in Transplantation Network. The network comprises 22 studies to date, including 16 494 transplant recipients and 11 669 donors, of whom more than 5000 are of non-European ancestry, all of whom have existing genomewide genotype data sets. Methods. We describe the rich genetic and phenotypic information available in this consortium comprising heart, kidney, liver, and lung transplant cohorts. Results. We demonstrate significant power in International Genetics & Translational Research in Transplantation Network to detect main effect association signals across regions such as the MHC region as well as genomewide for transplant outcomes that span all solid organs, such as graft survival, acute rejection, new onset of diabetes after transplantation, and for delayed graft function in kidney only. Conclusions. This consortium is designed and statistically powered to deliver pioneering insights into the genetic architecture of transplant-related outcomes across a range of different solid-organ transplant studies. The study design allows a spectrum of analyses to be performed including recipient-only analyses, donor-recipient HLA mismatches with focus on loss-of-function variants and nonsynonymous single nucleotide polymorphisms.

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Title: Design and Implementation of the International Genetics and Translational Research in Transplantation Network
Creators - without role: Brendan J. Keating - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Jessica van Setten - College Station Medical Center
Pamala A. Jacobson - University of Minnesota
Michael V. Holmes - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Shefali S. Verma - Pennsylvania State University
Hareesh R. Chandrupatla - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Nikhil Nair - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Hui Gao - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Yun R. Li - Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
Bao-Li Chang - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Chanel Wong - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Randy Phillips - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Brian S. Cole - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Eyas Mukhtar - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Weijia Zhang - Supreme Council Of Health
Hongzhi Cao - BGI
Maede Mohebnasab - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Cuiping Hou - Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
Takesha Lee - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Laura Steel - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Oren Shaked - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
James Garifallou - Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
Michael B. Miller - University of Minnesota
Konrad J. Karczewski - Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA
Abdullah Akdere - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Ana Gonzalez - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Kelsey M. Lloyd - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Daniel McGinn - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Zach Michaud - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Abigail Colasacco - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Monkol Lek - Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA
Yao Fu - Yale University
Mayur Pawashe - Yale University
Toumy Guettouche - Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
Aubree Himes - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Leat Perez - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Weihua Guan - University of Minnesota
Baolin Wu - University of Minnesota
David Schladt - College Station Medical Center
Madhav Menon - Supreme Council Of Health
Zhongyang Zhang - Supreme Council Of Health
Vinicius Tragante - College Station Medical Center
Nicolaas de Jonge - College Station Medical Center
Henny G. Otten - College Station Medical Center
Roel A. de Weger - College Station Medical Center
Ed A. van de Graaf - College Station Medical Center
Carla C. Baan - College Station Medical Center
Olivier C. Manintveld - College Station Medical Center
Iwijn De Vlaminck - Stanford University
Brian D. Piening - Stanford University
Calvin Strehl - Stanford University
Mary Shaw - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Harold Snieder - University of Groningen
Goran B. Klintmalm - Baylor University
Jacqueline G. O'Leary - Baylor University
Sandra Amaral - Childrens Hosp Philadelphia, Div Nephrol, Philadelphia, PA 19104 USA
Samuel Goldfarb - College Station Medical Center
Elizabeth Rand - Supreme Council Of Health
Joseph W. Rossano - Childrens Hosp Philadelphia, Div Pediat Cardiol, Philadelphia, PA 19104 USA
Utkarsh Kohli - Childrens Hosp Philadelphia, Div Pediat Cardiol, Philadelphia, PA 19104 USA
Peter Heeger - Supreme Council Of Health
Eli Stahl - Supreme Council Of Health
Jason D. Christie - Univ Penn, Div Pulm Allergy & Crit Care, Philadelphia, PA 19104 USA
Maria Hernandez Fuentes - Kings Coll London, London WC2R 2LS, England
John E. Levine - Univ Michigan, Blood & Marrow Transplant Program, Ann Arbor, MI 48109 USA
Richard Aplenc - Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA
Eric E. Schadt - Supreme Council Of Health
Barbara E. Stranger - University of Chicago
Jolanda Kluin - College Station Medical Center
Luciano Potena - University of Bologna
Andreas Zuckermann - University of Vienna
Kiran Khush - Stanford University
Alhusain J. Alzahrani - King Saud University
Fahad A. Al-Muhanna - Imam Abdulrahman Bin Faisal University
Amein K. Al-Ali - Imam Abdulrahman Bin Faisal University
Rudaynah Al-Ali - Imam Abdulrahman Bin Faisal University
Abdullah M. Al-Rubaish - Imam Abdulrahman Bin Faisal University
Samir Al-Mueilo - Imam Abdulrahman Bin Faisal University
Edna M. Byrne - University of Queensland
David Miller - University of Queensland
Stephen I. Alexander - University of Sydney
Suna Onengut-Gumuscu - University of Virginia
Stephen S. Rich - University of Virginia
Manikkam Suthanthiran - College Station Medical Center
Helio Tedesco - Hosp Rim & Hipertensao, Div Nephrol, Sao Paulo, Brazil
Chee L. Saw - McGill University
Jiannis Ragoussis - McGill University
Abdallah G. Kfoury - Intermt Heart Inst, Murray, UT USA
Benjamin Horne - Intermt Heart Inst, Murray, UT USA
John Carlquist - Intermt Heart Inst, Murray, UT USA
Mark B. Gerstein - University of Queensland
Roman Reindl-Schwaighofer - University of Vienna
Rainer Oberbauer - University of Vienna
Cisca Wijmenga - University of Groningen
Scott Palmer - Duke University
Alexandre C. Pereira - Supreme Council Of Health
Javier Segovia - Hosp Univ Puerta Hierro Majadahonda, Dept Cardiol, Heart Transplant Unit, Madrid, Spain
Luis A. Alonso-Pulpon - Hosp Univ Puerta Hierro Majadahonda, Dept Cardiol, Heart Transplant Unit, Madrid, Spain
Manuel Comez-Bueno - Hosp Univ Puerta Hierro Majadahonda, Dept Cardiol, Heart Transplant Unit, Madrid, Spain
Carlos Vilches - Hosp Univ Puerta Hierro Majadahonda, Dept Immunol, Madrid, Spain
Natalia Jaramillo - Hosp Univ Puerta Hierro Majadahonda, Dept Cardiol, Heart Transplant Unit, Madrid, Spain
Martin H. de Borst - University of Groningen
Maarten Naesens - Univ Hosp Leuven, Dept Nephrol & Renal Transplantat, Leuven, Belgium
Ke Hao - Supreme Council Of Health
DanielG MacArthur - Broad Institute
Suganthi Balasubramanian - Yale University
Peter J. Conlon - College Station Medical Center
Graham M. Lord - Kings Coll London, London WC2R 2LS, England
Marylyn D. Ritchie - Pennsylvania State University
Michael Snyder - Stanford University
Kim M. Olthoff - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Jason H. Moore - University of Virginia
Effie W. Petersdorf - Supreme Council Of Health
Malek Kamoun - Supreme Council Of Health
Jun Wang - BGI
Dimitri S. Monos - Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
Paul I. W. de Bakker - College Station Medical Center
Hakon Hakonarson - Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
Barbara Murphy - Supreme Council Of Health
Matthew B. Lankree - McMaster University
Pablo Garcia-Pavia - Hosp Univ Puerta Hierro Majadahonda, Dept Cardiol, Heart Transplant Unit, Madrid, Spain
William S. Oetting - University of Minnesota
Kelly A. Birdwell - Vanderbilt University
Stephan J. L. Bakker - University of Groningen
Ajay K. Israni - University of Minnesota
Abraham Shaked - Hosp Univ Penn, Penn Transplant Inst, Philadelphia, PA 19104 USA
Folkert W. Asselbergs - College Station Medical Center
Int Genetics & Translational Res T
Publication Details: Transplantation, Vol.99(11), pp.2401-2412
Publisher: Lippincott Williams & Wilkins
Number of pages: 12
Grant note: U01HG006830 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) R01AI054115 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) MR/K500999/1 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission U19 AI070119; U01 AI058013; U01 AI063589; R01 AI054115; UM1 AI109565 / NIAID NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) U01 DK062494; P01 DK013083 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) NF-SI-0512-10074 / National Institute for Health Research; National Institute for Health Research (NIHR) U01DK062494 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) U01 HG006830 / NHGRI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI)
Identifiers: 9914217208331
Academic Unit: Hafr Albatin University; King Saud University; Imam Abdulrahman Bin Faisal University
Language: English
Resource Type: Journal article