Abstract
Lornoxicam (LOR) is a poor water soluble non- steroidal anti-inflammatory drug. It has low dissolution rate-in acidic pH media. The objective was to develop LOR self-nanoemuisifying drug delivery systems (SNEDDS) to improve its dissolution rate. LOR SNEDDS were prepared using blends of different surfactants. Formulations were evaluated for its spontaneous emulsification, droplet size, turbidity and in vitro dissolution. LOR SNEDDS (F31) that consisted of Cremophore (R) RH 40, Cremophore (R) EL and Tween 80 in a ratio of 1:1:1 (w/w) showed the best physicochemical properties among the tested formulations. Comparative dissolution study was performed between F31 and market product, Xefo (R) tablets. The dissolution study were performed in 0.1N HCl showed that the dissolution of LOR from F31 reached 49.7% after 5 min and 91.6% after 60 min meaning that SNEDDS improved the solubility of LOR in acidic condition which could lead to higher absorption and lower its onset time.