Abstract
In this article, we reported a new library of arylthiadiazole analogs of imidazopyridines (9 a-j) designed based on the structures of Nocodazole and Cefozopran. After characterization by spectroscopic data, the synthesized analogs were assessed for anticancer potential using MTT assay against PC3, A549, MCF-7 and DU-145 human cancer cell lines. Etoposide, an anticancer medication candidate, was employed as a positive control. The anticancer activity of the synthesized analogues was expressed in IC50 ranging from 0.01 +/- 0.008 mu M to 19.3 +/- 7.65 mu M and compared with positive control. Five compounds 9 d, 9 e, 9 g, 9 h and 9 j possessed more potent anticancer properties.