Abstract
IN this present work, synthesized a novel derivatives of his-chalcones via condensation of 1,4-diacetylbenzene with different aldehydes in basic media. The reaction of chalcone derivatives 3a,b with thioglycolic acid gave compounds -1a,b. That was reacted with ethyl cyanoacetate in presence of ammonium acetate to give the corresponding cyanopyridine derivatives Sa,b. Furthermore, bis-chalcone 3a,b was cyclization to pyrazole analogs by using 2,4-dinitrophenythydrazine to give compounds 7a,b in good yields. All products were characterized by IR spectrum, "CNMR, and elemental analysis. The new compounds have been screened as anti -bacterial activity