Abstract
Novel 6-(1,2,3-triazol-4-yl)-5-[(2-(thiazol-2-yl) hydrazono) methyl] imidazo[2,1-b] thiazoles 7, 9a-d, and 11 were prepared by reaction of thiosemicarbazone 5a, b with either hydrazonoyl chloride 6, phenacylbromides 8 or 2-bromo-1-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl) ethanone 10 respectively. The new products were tested for their antimicrobial activities using 96-well micro-plate assay, and compound 7 showed excellent antibacterial activities compared with Vancomycine (reference drugs), while compounds 5b and 9c exhibited good results against yeast. The minimum inhibitory concentration (MIC) was determined, and compound 7 showed the lowest MIC against Gram positive bacteria while compound 5b showed the lowest MIC against yeast.