Abstract
An efficient protocol for the synthesis of a new series of oxazolidin-2-ones containing sulfamide moieties is described. The synthesis was achieved in two reaction steps. The first was carried out under anhydrous conditions at 0 °C through a selective addition of an alcohol and primary amines to chlorosulfonylisocyanate to produce N-carboxylsulfamides in good yields. Under appropriate conditions of solvent, base and temperature, these intermediates underwent subsequent intramolecular cyclizations, giving exclusively the corresponding sulfamoyloxazolidinones.
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