Abstract
•Charge transfer complexes have gained interest in pharmacology.•Charge transfer complexes help study drug pharmacodynamics and thermodynamics.•Charge transfer interaction affects anticancer and antimicrobial activity.•The produced complexes had higher anticancer and antimicrobial activity.•Biochemical tests showed complexation didn't worsen ciprofloxacin side effects.
Ciprofloxacin (CIP) is a common antibiotic drug used as a strudy electron donor that interacts with dynamic π-acceptors such as 2,3-dinitrosalsylic acid (HDNS) and Tetracyanoethylene (TCNE) for synthesizing a new model of charge transfer (CT) complexes. The synthesized complexes were identified using diverse analytical methods such as UV–vis spectra, photometric titration measurements, FT-IR, 1H NMR Spectroscopy, and thermogravimetric analysis techniques (TGA/DTA). The stoichiometries for all the formed complexes were found to be 1:1 M ratio between the reactants. The characteristic spectroscopic properties such as transition dipole moment (μ), oscillator strength (ƒ), formation constant (KCT), ionization potential (ID), standard free energy (ΔG), and energy of interaction (ECT) for the CT-complexes were collected. The developed CT-complexes were tested for their toxicity on main organs, antimicrobial activity, antioxidant activity, and biofilm formation.