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Design, synthesis and evaluation of novel 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4-substituted phenyl methanone analogues
Journal article   Peer reviewed

Design, synthesis and evaluation of novel 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4-substituted phenyl methanone analogues

Mohamed Ashraf Ali, Mohammad Shahar Yar, Mohamed Zaheen Hasan, Mohamed Jawed Ahsan and Suresh Pandian
Bioorganic & medicinal chemistry letters, Vol.19(17), pp.5075-5077
01/09/2009
DOI: https://doi.org/10.1016/j.bmcl.2009.07.042
PMID: 19643609

Abstract

Acetylcholinesterase - chemistry Acetylcholinesterase - metabolism Alzheimer Disease - drug therapy Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Drug Design Humans Indenes - chemical synthesis Indenes - chemistry Indenes - pharmacology Neuroprotective Agents - chemical synthesis Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology
In present investigation, a series of substituted phenyl-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenylmethanone analogues were synthesized and were tested for their potential for treating AD disease. All the newly synthesized compounds were showing moderate to high AChE inhibitory activities, with compound 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4,5-trimethoxyphenylmethanone (5f) produced significant activities with 2.7+/-0.01 micromol/L.

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