Abstract
A series of 2-(naphthalen-2-yloxy)propionic acid derivatives were prepared. The hypolipidemic activity of the new compounds as well as the intermediate acid
2 was evaluated in the high cholesterol diet (HCD) fed hyperlipidemic rat model. Interestingly, the
S-alkylated mercaptotriazole
8b and the 1,3,4-oxadiazole
9 produced striking reduction of serum levels of total cholesterol (TC), triglycerides (TGs) and low-density lipoproteins (LDLs) and elevation of serum high-density lipoproteins (HDLs) being more active than the reference gemfibrozil. In addition, the 1,2,4-triazole
7a, the hydroxypyrazoline
10 and the pyrazolone derivative
11 exhibited good hypolipidemic activity on different lipid parameters.
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