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Design, synthesis and hypolipidemic activity of novel 2-(m-tolyloxy) isobutyric acid derivatives
Journal article   Peer reviewed

Design, synthesis and hypolipidemic activity of novel 2-(m-tolyloxy) isobutyric acid derivatives

Gamal A. Idrees, Gamal El-Din A. Abuo-Rahma, Omar M. Aly and Mohamed F. Radwan
European journal of medicinal chemistry, Vol.44(6), pp.2679-2684
01/06/2009
DOI: https://doi.org/10.1016/j.ejmech.2008.12.009
PMID: 19121550

Abstract

Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology
Novel 2-substituted isobutyric acid derivatives were synthesized and their hypolipidemic activity was evaluated in high cholesterol diet fed rat model. The amide Sa was found to decrease the levels of serum total cholesterol, LDL cholesterol and triglycerides in hyperlipidemic rats to a greater degree than the reference gemfibrozil. (C) 2008 Elsevier Masson SAS. All rights reserved.

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