Abstract
Nine new purine-based compounds were designed and have been synthesized through series reactions of the starting compound 8-amino-substituted purine (2) with various reagents. Full characterizations of the synthesized compounds were performed to elucidate their chemical structures by means of physical and spectroscopic methods. All products were in-vitro tested for their potent anti-cancer action against different human cancers; leukemia (HL60), lung cancer (A549), Breast cancer (SKBR3) and Stomach cancer (MKN45). Upon experimental biological evaluation, synthons showed higher efficiency against SKBR3 cell lines in particular and hence were docked with anticancer enzyme (Aurora kinase) to adequately understand the link of each entity inside the enzyme active site. (C) 2020 Elsevier B.V. All rights reserved.