Abstract
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•Novel aminothiohydantoin Schiff base (ATHSB) and its metal complexes were successfully prepared.•New compounds were structurally and morphologically characterized using various techniques.•Thermal analysis denotes the thermal stability of new compounds.•Comparative in-vitro anticancer studies of free ligand and metal complexes were addressed.•Complex Zn(II)ATHSB was found to be most promising anticancer candidate.
A novel aminothiohydantoin Schiff base (ATHSB) ligand and its complexes {M(II)ATHSB; M = Mn(II), Cu(II), Zn(II)} have been successfully synthesized. The coordination modes, stoichiometry, geometry, thermal stability, and morphology of M(II)ATHSB were deduced based upon the outputs of different physicochemical, spectroscopic, and microscopic techniques. The comparative in-vitro anticancer studies revealed that all complexes are more cytotoxic than the parent ligands against human cancer cell lines (liver carcinoma (HepG2), colon carcinoma (HCT116)), whereas, they exhibited lower toxicity as compared to the free ligand against normal liver cells (HL7702). Complex Zn(II)ATHSB seems to be a superlative candidate; as it is the most cytotoxic one against HepG2 concomitantly with lowest toxicity toward the normal human liver cells (HL7702), thus may offering a potential alternative for conventional cancer chemotherapeutic agents.