Design, synthesis, characterization, computational study and in-vitro antioxidant and anti-inflammatory activities of few novel 6-aryl substituted pyrimidine azo dyes

Aziz Unnisa; Amr S. Abouzied; Anupama Baratam; K. N. V. Chenchu Lakshmi; Talib Hussain; Rama Devi Kunduru; Humera Banu; Syeda Bushra Fatima; Arshad Hussian; Kesavanarayanan Krishnan Selvarajan

doi:10.1016/j.arabjc.2020.09.050

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Design, synthesis, characterization, computational study and in-vitro antioxidant and anti-inflammatory activities of few novel 6-aryl substituted pyrimidine azo dyes

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Design, synthesis, characterization, computational study and in-vitro antioxidant and anti-inflammatory activities of few novel 6-aryl substituted pyrimidine azo dyes

Aziz Unnisa, Amr S. Abouzied, Anupama Baratam, K. N. V. Chenchu Lakshmi, Talib Hussain, Rama Devi Kunduru, Humera Banu, Syeda Bushra Fatima, Arshad Hussian and Kesavanarayanan Krishnan Selvarajan

Arabian journal of chemistry, Vol.13(12), pp.8638-8649

01/12/2020

DOI: https://doi.org/10.1016/j.arabjc.2020.09.050

Abstract

Chemistry

Chemistry, Multidisciplinary

Physical Sciences

Science & Technology

A series of 6-aryl substituted pyrimidine azodyes were synthesized by coupling of phenyl pyrimidine 2-amine with different aromatic amines. The synthetic compounds were screened for their in-vitro antioxidant and anti-inflammatory activities. The characterization of the synthesized compounds was carried out by IR, H-1 NMR, C-13 NMR and Mass spectrophotometry. Computational study of designed compounds was done by OCHEM, Molinspiration cheminformatics, Datawarrior, and Swiss ADME. DPPH assay was used to determine the antioxidant activity and heat hemolysis method for anti-inflammatory activity. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

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Title: Design, synthesis, characterization, computational study and in-vitro antioxidant and anti-inflammatory activities of few novel 6-aryl substituted pyrimidine azo dyes
Creators - without role: Aziz Unnisa - University of Ha'il
Amr S. Abouzied - University of Ha'il
Anupama Baratam - Siddhartha Medical College
K. N. V. Chenchu Lakshmi - Department of Pharmaceutical Chemistry, QIS College of Pharmacy, Andhra Pradesh, India
Talib Hussain - University of Ha'il
Rama Devi Kunduru - University of Ha'il
Humera Banu - University of Ha'il
Syeda Bushra Fatima - University of Ha'il
Arshad Hussian - University of Ha'il
Kesavanarayanan Krishnan Selvarajan - University of Ha'il
Publication Details: Arabian journal of chemistry, Vol.13(12), pp.8638-8649
Publisher: Elsevier
Number of pages: 12
Grant note: RG-191339 / Scientific Research Deanship at the University of Ha'il - Saudi Arabia
Identifiers: 9932071908331
Academic Unit: University Ha'il
Language: English
Resource Type: Journal article