Abstract
A new series of phenytoin derivatives 4 a‐j have been designed via one‐pot three component reaction of aryl aldehyde derivatives 1 a‐j with thiosemicarbazide (2) and benzil (3) in presence of sodium alkoxide. The structure of new target phenytoin derivatives 4 a‐j was assigned on the basis of elemental and spectral data. The newly synthesized products have been screened and studied as anti‐inflammatory effectiveness compared to ibuprofen as a reference drug. It has been found that is compounds 4 b, 4 d, 4 h, 4 f and 4 j exhibit excellent anti‐inflammatory properties compere to ibuprofen.
Novel series of phenytoin derivatives 4 a‐j were synthesized via one‐pot three component reaction of aryl aldehydes 1 a‐j with thiosemicarbazide (2) and benzil (3) in presence of sodium alkoxide. The structure of these products 4 a‐j were assigned on the basis of analytical and spectral data. All of these compounds were screened as anti‐inflammatory, it has been observed that all the tested products display considerable anti‐inflammatory activity.