Abstract
Aim: To examine the prognostic factors of renal survival and relapse in anti-neutrophil cytoplasm antibody associated vasculitis with long term follow-up.
Study Design: Retrospective cohort study.
Place & Duration of Study: Department of Nephrology, Shaikh Zayed Hospital Lahore from 1st January 2018 to 30th June 2018.
Methods: In this study total 35 patients of both sex with renal biopsy-proven anti neutrophil cytoplasm antibody associated vasculitis were included. Patients ages were >35 years. Complete follow-up of more than 15 years was taken to examine the renal survival and relapse.
Results: There were 22 (62.86%) males and 13 (37.14%) patients were females. Ten (28.57%) patients were of ages between 35 to 50 years and 25 (71.43%) patients had ages more than 50 years. Nineteen patients (54.29%) had microscopic polyangitis and 45.71% patients had diagnosis with granulomatosis with polyangiitis. Histopathological examination was recorded as focal, crescentic, mixed and sclerotic glomerulonephritis in 11 (31.43%). 10 (28.57%), 8 (22.86%) and 6 (17.14%) patients. According to treatment, cyclophosphamide with corticosteroids were given to 80% and azithoprine with corticosteroids in 74.29%. The fifteen year patients survival was 15 (42.86%). We observed patients with ages more than 55 years and myeloperoxidase anti-neutrophil cytoplasm antibody were associated with shorter patient's survival time. Renal survival was noted in 23 (65.71%). At 15 years follow-up relapse free survival was 11.43%.
Conclusion: The patients and renal survival in anti-neutrophil cytoplasm antibody associated vasculitis with glomerulonephritis had better results as compared to relapse