Abstract
•The increasing burden of DM threatens the progress in reducing TB-related mortality in most of the developing countries.•DM increases the risk of TB and worsen the TB treatment outcome, particularly when gets uncontrolled.•DM increases the incidence of ADRs and impairs the patients’ health-related quality of life in TB patients.•The integrated approach including bidirectional screening and coordinated management needs to be emphasized.•Studies elucidating the underlying cellular mechanisms to identify new therapeutic targets should be encouraged.
Despite significant efforts made to control tuberculosis (TB) through DOTS program, the increasing burden of diabetes mellitus (DM) threatens the progress in reducing TB-related mortality, particularly in developing countries. In recent years, TB-DM comorbidity continues to remain high in countries where DM is on rampant. DM increases the risk of TB, reactivates the dormant TB and worsens the TB treatment outcome. The present review highlights the current findings regarding the prevalence and association of TB-DM comorbidity along with their public health implications. This review will increase the awareness among researchers, policymakers and clinicians, regarding the current scenario of TB-DM association.