Abstract
The study aimed to develop novel lornoxicam (LOR)-loaded cubosomes (CS) consisting of glycerol monooleate (GMO) and poloxamer 407 in comparison with flexible liposomes (FL) to enhance the skin penetration of LOR. These formulations have been described as possible carriers to deliver drug molecules to the skin layers. The efficacy of the prepared systems was compared with conventional liposomes (LP) and LOR solution. These systems were characterized for particle size, entrapment efficiency (EE %), stability and the morphology. Furthermore, ex vivo penetration activity were evaluated. It was found that the presence of PL 407 and sodium cholate (NaC) played an important role in the vesicle size reduction to nano range. The transmission electron microscopy (TEM) images and X-ray diffraction revealed the formation of cubic structure. Moreover; CS enhanced the amount of LOR in SC and deeper skin layers compared to LP and FL. It can be concluded that cubosomes in the presence of GMO and PL 407 may be a promising carrier for effective skin delivery of LOR.