Abstract
New bio-composite nanofibers composed of polyethylene oxide (PEO)/silk fibroin (SF)/barium titanate (BaTiO
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) are introduced in this study. The SF solution was added to the PEO solution to form a PEO/SF blend with different weight percentages (5, 10, 15, 20 wt.%). The PEO/15 wt.% SF blend was selected to continue the experimental plan based on the optimum nanofiber morphology. Different wt.% of BaTiO
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particles (0.2, 0.4, 0.8, 1 wt.%) were added to the PEO/15 wt.% SF blend solution, and the suspensions obtained were introduced to an electrospinning device. The fabricated tissue was characterized by scanning electron microscope (SEM), X-ray diffraction (XRD) and Fourier-transform infrared (FTIR) spectroscopy. The zeta potential of the solution and the piezoelectric performance of the fabricated tissue were characterized. A newly designed pizoTester was used to investigate piezoelectric properties. The results showed that a well-organized, smooth PEO/15 wt.% SF/0.2 wt.% BaTiO
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nanofiber composite with low bead contents was obtained. Improved properties and electrical coupling were achieved in the newly introduced material. Electrospun PEO/15 wt.% SF/0.2 wt.% BaTiO
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mats increased the output voltage (1150 mV) compared to pristine PEO and PEO/SF composite fibers (410 and 290 mV, respectively) upon applying 20 N force at 5 Hz frequency. The observed enhancement in piezoelectric properties suggests that the prepared composite could be a promising material in cardiac tissue engineering (CTE).