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Development of oxacillin resistance in a patient with recurrent Staphylococcus aureus bacteremia
Journal article   Peer reviewed

Development of oxacillin resistance in a patient with recurrent Staphylococcus aureus bacteremia

Eileen M Burd, Mohammad Tauqeer Alam, Karla D Passalacqua, Ameeta S Kalokhe, Molly E Eaton, Sarah W Satola, Colleen S Kraft and Timothy D Read
Journal of clinical microbiology, Vol.52(8), pp.3114-3117
01/08/2014
DOI: https://doi.org/10.1128/JCM.00615-14
PMCID: PMC4136127
PMID: 24850355

Abstract

Aged, 80 and over Anti-Bacterial Agents - pharmacology ATP-Binding Cassette Transporters - genetics Bacteremia - microbiology DNA, Bacterial - chemistry DNA, Bacterial - genetics Drug Resistance, Bacterial Frameshift Mutation Genome, Bacterial Humans Longitudinal Studies Male Microbial Sensitivity Tests Molecular Sequence Data Mutagenesis, Insertional Oxacillin - pharmacology Recurrence Sequence Analysis, DNA Staphylococcal Infections - microbiology Staphylococcus aureus - drug effects Staphylococcus aureus - isolation & purification
Whole-genome sequencing was used to compare longitudinal isolates of Staphylococcus aureus that developed resistance to oxacillin (MIC up to 16 μg/ml). The mecA gene was absent. A novel 5-bp TATCC frameshift insertion in a gene encoding an ABC transporter similar to that of the teichoic acid translocation ATP-binding protein TagH and a 3-bp GCT nonframeshift insertion in the pdhA pyruvate dehydrogenase gene were detected in the oxacillin-resistant isolates.

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