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Diastereoselective photochemical synthesis of alpha-amino-beta-hydroxyketones by photocycloaddition of carbonyl compounds to 2,5-dimethyl-4-isobutyloxazole
Journal article   Peer reviewed

Diastereoselective photochemical synthesis of alpha-amino-beta-hydroxyketones by photocycloaddition of carbonyl compounds to 2,5-dimethyl-4-isobutyloxazole

Samir Bondock and Axel G. Griesbeck
Monatshefte für Chemie, Vol.137(6), pp.765-777
01/06/2006

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
The photocycloaddition of aldehydes and alpha-ketoesters to 2,5-dimethyl-4-isobutyloxazole leads to bicyclic oxetanes with high to moderate (exo) diastereoselectivity that can be easily ring-opened to give alpha-amino-beta-hydroxyketones.

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