Abstract
A fast, efficient, and diastereoselective synthesis of novel 3-oxo-4-benzothiazolylpyrazolyl--lactams is described. The reaction between 2-aryloxy/alkoxyacetic acid and novel benzothiazolylpyrazole-substituted imines afforded exclusive formation of trans--lactams. The scope of the reaction was investigated by varying different groups on substrates (R-1, R-2, R-3, Z). All the novel compounds were characterized using various spectroscopic techniques such as FT-IR, H-1 NMR, C-13 NMR, elemental analysis, and mass spectrometry in representative cases. No report has been listed in the literature for the synthesis of these types of -lactam heterocycles so far.