Abstract
Background: The nearby similarity of the coronaviruses (SARS-CoV, SARS-CoV-2, and MERS-CoV) intimating the possibility of shared immunization. Therefore, this study aimed to assess the differences and similarities between COVID-19 and MERS-CoV: the prospect of co-immunization. Methodology: This study included a cross-sectional random survey that recruited 211 contributors living in the city of Hail, Northern Saudi Arabia, during the period from April 2020 to March 2021. A purposeful electronic questionnaire was deliberated and distributed via various social media sets, regardless of age or gender. Information linked to previous MERS-CoV or COVID19 previous infection was collected. The study population included two groups. Group one: tested for MERS-CoV or COVID19 and found positive. Results: COVID19 and MERS-CoV infections were revealed in 28% and 27% of persons, respectively. Out of the 55 patients infected with MERS-CoV, 24/55(43.6%) were subsequently infected with COVID19. The risk of COVID19 infection associated with previous MERS-Cov infection, Odds Ratio (OR) and 95% confidence interval (95%CI), OR (95%CI) = 2.782(1.436-5.391), P-value = 0.002. Out of 21 persons with a family history of MERS-CoV, 7/21(33%) were subsequently infected with COVID19. Conclusion: Previous MERS-CoV infection does not precludelater COVID19 infection. People with previous MERS-CoV infection are more susceptible to COVID19 infection. Males and older individuals are more susceptible to be infected with COVID19 with severe clinical manifestations.