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Diminished Bone Formation During Diabetic Fracture Healing Is Related to the Premature Resorption of Cartilage Associated With Increased Osteoclast Activity
Journal article   Open access  Peer reviewed

Diminished Bone Formation During Diabetic Fracture Healing Is Related to the Premature Resorption of Cartilage Associated With Increased Osteoclast Activity

Rayyan A Kayal, Dimitris Tsatsas, Megan A Bauer, Brian Allen, Maisa O Al-Sebaei, Sanjeev Kakar, Cataldo W Leone, Elise F Morgan, Louis C Gerstenfeld, Thomas A Einhorn, …
Journal of bone and mineral research, Vol.22(4), pp.560-568
04/2007
DOI: https://doi.org/10.1359/jbmr.070115
PMCID: PMC3109431
PMID: 17243865

Abstract

cartilage diabetes endochondral bone fracture hyperglycemia osteoclast
Histological and molecular analysis of fracture healing in normal and diabetic animals showed significantly enhanced removal of cartilage in diabetic animals. Increased cartilage turnover was associated with elevated osteoclast numbers, a higher expression of genes that promote osteoclastogenesis, and diminished primary bone formation.
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https://doi.org/10.1359/jbmr.070115View
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