Abstract
In this study, the dipole moment of alpha-hydroxy-beta-lactam derivatives are discussed in detail. Both the hydroxy and acetoxy derivatives of monocyclic cis and trans beta-lactam are considered for this investigation. The influence of the substituted group at N-1 position on the polarity is also investigated. Four quantum mechanical methods (AM1, RM1, PM3 and PM6) are chosen to calculate dipole moment of these molecules. Best of our knowledge, this is the first study on the dipole moment of hydroxy beta-lactam derivatives which are related to taxol and taxotere anticancer agents.