Abstract
A metal‐free, simple, and highly efficient method for the direct alkylation of non‐basic heterocycles and basic ones with various alcohols and cyclic ethers has been developed based on an oxidative C–H activation process. The corresponding products were generated through a dehydrogenative C–C cross‐coupling reaction in the presence of di‐tert‐butyl peroxide in good to high yields.
A metal‐free direct alkylation reaction of non‐basic nitrogen‐free heterocycles and basic nitrogen‐containing ones with alcohols and cyclic ethers in the presence of di‐tert‐butyl peroxide is described.