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Direct catalytic asymmetric three-component Mannich reactions with dihydroxyacetone: enantio selective synthesis of amino sugar derivatives
Journal article   Peer reviewed

Direct catalytic asymmetric three-component Mannich reactions with dihydroxyacetone: enantio selective synthesis of amino sugar derivatives

Pawel Dziedzic, Ismail Ibrahem and Armando Cordova
Tetrahedron letters, Vol.49(5), pp.803-807
28/01/2008
DOI: https://doi.org/10.1016/j.tetlet.2007.11.196

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Highly enantioselective, amino acid-catalyzed, one-pot three-component asymmetric Mannich reactions between dihydroxyacetone, p-anisidine, and aldehydes are presented. The reactions proceeded with high chemo- and stereoselectivity and furnished the corresponding alpha, alpha'-dihydroxy-beta-aminoketones in high yields with 82-95% ee. (C) 2007 Elsevier Ltd. All rights reserved.

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